• Overcoming taxane resistance in cancer

    Updated: 2010-01-31 07:23:31
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags animals cells mice resistance taxol Overcoming taxane resistance in cancer Posted on 31 January 2010 07:23 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary When they suppressed prohibitin1 with RNA interference techniques , the tumor cells became more susceptible to Taxol , both in cell culture and in live mice with implanted Taxol-resistant tumors . We are working to target various cancer drugs to taxane-resistant cells by attaching them to compounds that bind to prohibitin , Zetter explains . One such compound is already known , and works well in animals to target other prohibitin-rich cells , but has yet to be tested in humans . His lab is in talks with several cancer centers to obtain serum samples from patients who did and didnt respond to Taxol , so that prohibitin1 levels could be measured and compared . The interesting finding was that prohibitin was not just another over-expressed protein , Zetter says . When we looked at the whole cell , the absolute amount of prohibitin wasnt changed . Instead , prohibitin was moving from the

  • Alcohol during pregnancy chemically alters fetal DNA

    Updated: 2010-01-31 02:50:31
    Story Summary: Now experiments in mice suggest this may be because alcohol chemically alters the fetuss DNA, affecting how genes are expressed. Its well known that fetal alcohol syndromeoccurs when pregnant women drink excessively and causes behavioural and physical harm to the child after birth. This will yield a predictable ratio of brown, yellow and [...] Related posts:Mothers boozing alters offsprings genes, in mice Maternal Immune Response To Fetal Brain During Pregnancy A Key Factor In Some Autism Alcohol, Pregnancy And Brain Cell Death

  • Bats and dolphins separately evolved same sonar gene

    Updated: 2010-01-31 01:19:31
    Story Summary: Analysis of a specific gene has now demonstrated that although bats live in air and dolphins in water, where sound travels five times faster, they independently evolved a near-identical gene that allows them to accept high-frequency sound in the ear – vital for sonar. The gene makes prestin, a protein in hair cells [...] Related posts:Three human genes evolved from junk Three human genes evolved from junk Which virus will birds give us next?

  • Horizontal and vertical: The evolution of evolution

    Updated: 2010-01-30 23:48:31
    : Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags 26 january conclusion isolation proportion woese Horizontal and vertical : The evolution of evolution Posted on 30 January 2010 23:48 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary According to Woese and Goldenfeld , they are profound , and horizontal gene transfer alters the evolutionary process itself . Their arguments make sense and their conclusion is very important , says biologist Jan Sapp of York University in Toronto , Canada . The process of evolution just isnt what most evolutionary biologists think it is . Vertical hegemonyHow could modern biology have gone so badly off track Biology built up a facade of mathematics around the juxtaposition of Mendelian genetics with Darwinism , he says . In particular , he argues , nothing in the modern synthesis explains the most fundamental steps in early life : how evolution could have produced the genetic code and the basic genetic machinery used by all organisms , especially the enzymes and structures involved in translating genetic information into proteins . That was a big mistake ,

  • Genetic research: The fight against disease gets personal

    Updated: 2010-01-30 22:17:31
    Story Summary: Venter recalls Nirenberg as a reserved, softly spoken man, who was both supporter and mentor. He taught us how to interpret the letters of the code, Venter told me this week. All of a sudden, we understood how to read it. In the end, a bitterly contested race developed between Venter and an [...] Related posts:Illumina launches personal genome sequencing service for $48,000 : Genetic Future Risks of Sharing Personal Genetic Information Online Need More Study, Stanford Bioethicists Say Blog – Personal Genomes Get Very Personal

  • Lab-grown Liver Cells Provide Model for Hepatitis C Infection

    Updated: 2010-01-30 20:46:31
    Story Summary: Using the new cell culture system, scientists can now study hepatitis C virus in the lab over a period of weeks – which may boost efforts to develop a vaccine or broadly effective treatment for the infection. Until now, scientists working on hepatitis C vaccine design have been hampered by the lack of [...] Related posts:Liver cells grown from patients skin cells Keeping hepatitis C virus at bay after a liver transplant Natural compound blocks hepatitis C infection

  • Hiding place for missing heritability uncovered

    Updated: 2010-01-30 19:15:31
    Story Summary: However, Goldstein speculated that rare mutations that are too low in frequency to be uncovered by GWA studies might be hiding within the common variants and throwing off the signal. Leonid Kruglyak, a geneticist at Princeton University in New Jersey, says the work confirms what many had suspected. I think everyone who thought [...] Related posts:Rare genetic variants create synthetic genome-wide signals of disease risk Nine new X chromosome genes associated with learning disabilities uncovered Nine new X chromosome genes associated with learning disabilities uncovered

  • New compound could be alternative strategy for preventing HIV infection

    Updated: 2010-01-30 17:44:31
    Story Summary: Now, researchers want to improve these drug therapies and develop alternative preventative strategies, such as vaginal gels and creams that contain the same or related compounds used in treatments for people infected with HIV. A University of Missouri researcher is developing a compound that is more potent and longer-lasting than current HIV therapies. [...] Related posts:Natural compound blocks hepatitis C infection Natural compound blocks hepatitis C infection, UCLA study finds Natural compound blocks hepatitis C infection, UCLA study finds

  • Genome sequencing study finds clues to unravelling the causes of deadly epidemics

    Updated: 2010-01-30 16:13:31
    Story Summary: In some cases, patients suffer from a devastating infection of tissue and muscle requiring extensive surgery. Understanding the detailed molecular architecture of bacterial epidemics has been a long-sought goal of infectious disease research, he added. Genetics and evolution research has long been hobbled by the lack of comprehensive genome-wide markers. The recent advent [...] Related posts:Genome Sequencing Study Finds Clues to Unraveling the Causes of Deadly Epidemics Falling birth rates shift rotavirus epidemics Falling birth rates shift rotavirus epidemics

  • Discovery of epigenetic memory during breast cancer

    Updated: 2010-01-30 14:42:31
    Story Summary: The findings, which appear online in Cancer Research, may lead to the development of new therapeutic strategies for late stage breast and other cancers. According to the researchers, it is becoming increasingly accepted that changes that do not affect the genetic blueprint or DNA sequence, known as the epigenetic landscape, play a major [...] Related posts:Breast cancer gene discovery most important for 20 years Researcher Awarded $1.6 Million To Investigate Tumor Suppressors Role In Breast Cancer Discovery leads to rapid mouse personalized trials in breast cancer

  • Engineering a new way to study hepatitis C

    Updated: 2010-01-30 13:11:31
    Story Summary: The researchers used healthy liver cells that had been cryogenically preserved and grew them on special plates with micropatterns that direct the cells where to grow. If you specify which cells sit next to each other, you can extend the lifetime of the cells and help them maintain their function. The current system [...] Related posts:Largest-ever database for liver proteins may lead to treatments for hepatitis Geneticists hunt for scleroderma triggers Whooping cough immunity lasts longer than previously thought

  • Alliance for Regenerative Medicine Meets With Federal Multi-Agency Tissue Engineering Science Interagency Working Group (MATES IWG)

    Updated: 2010-01-30 11:40:31
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags medicine member agencies patient groups principal purpose tissue engineering Alliance for Regenerative Medicine Meets With Federal Multi-Agency Tissue Engineering Science Interagency Working Group MATES IWG Posted on 30 January 2010 11:40 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary This was an important first step toward coalescing unified support around the cause of regenerative medicine . The Multi-Agency Tissue Engineering Science MATES Interagency Working Group IWG organized under the auspices of the Subcommittee on Biotechnology of the National Science and Technology Council NSTC was established in 2000. The principal purpose of the MATES IWG is to provide a platform across which member agencies can interact and exchange information on tissue engineering efficiently and effectively . It is the means by which Federal agencies involved in tissue engineering stay informed of each others activities and coordinate their efforts in a timely and efficient manner . ARM also works to increase public understanding of the field and its

  • Researchers at Signature Genomics Attribute Diverse Spectrum of Brain and Facial Anomalies to Genetic Regions Associated with Holoprosencephaly

    Updated: 2010-01-30 10:09:31
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags abnormality brain chromosome 13 neurologists obstetricians Researchers at Signature Genomics Attribute Diverse Spectrum of Brain and Facial Anomalies to Genetic Regions Associated with Holoprosencephaly Posted on 30 January 2010 10:09 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary The results of the study , which were published in the journal Human Genetics , showed that most cases with holoprosencephaly had deletions of one of four major holoprosencephaly genes , which is consistent with previous studies . Researchers also identified a previously unreported abnormality associated with holoprosencephaly , an extra piece of DNA on one copy of chromosome 13, which was identified in two individuals with holoprosencephaly , one with a full form of the disorder and one with a mild form . aThese results are exciting because they demonstrate how microarray testing allows us to broaden the clinical spectrum associated with various chromosome aberrations,a said Lisa G . Shaffer , Ph . D . President and CEO of Signature Genomic Laboratories and

  • Dynavax Reports Positive Phase 1b Data for SD-101 in Chronic Hepatitis C Infection

    Updated: 2010-01-30 07:07:31
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags acquisition adult clinical stage interferon alpha product candidate Dynavax Reports Positive Phase 1b Data for SD-101 in Chronic Hepatitis C Infection Posted on 30 January 2010 07:07 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary According to the Companys Chief Medical Officer , J . Tyler Martin , M . D . The unique and highly potent pattern of IFN-lambda and IFN-alpha induction by SD-101 represents a novel , differentiated approach for HCV . The safety and antiviral activity demonstrated in this Phase 1b study compares favorably to current treatments , and we believe that further study may support a role for SD-101 as a supplement to current or emerging therapies to treat HCV . With the completed acquisition of Symphony Dynamo earlier this month , Dynavax has full development and commercialization rights to SD-101. Over 80 of HCV infections become chronic and can progress over a period of 10 40 years . Nearly half of all liver transplants in the U . S . are performed for end-stage hepatitis C . Approved therapies to treat hepatitis C ,

  • BioServe and Fox Chase Cancer Center Form Strategic Alliance to Accelerate Biomarker and Genetic Discovery

    Updated: 2010-01-30 05:36:31
    Story Summary: Fox Chase specimens collected at each stage are supported by annotations that include medical histories, detailed records of treatment protocols as well as outcomes. We know that making our biosamples available to the wider scientific community will accelerate the pace of cancer research. With this goal in mind, partnering with BioServe makes a [...] Related posts:Predicting patient response to gleevec in gastrointestinal stromal tumors Covance Enters Into a Biomarker Alliance With Rules-Based Medicine, Inc. NCI renews Fox Chase / Penn Ovarian Cancer SPORE grant for a third 5-year term

  • Coriell Institute Receives $27M for Human Genetics Biobank and New Stem Cell Laboratory

    Updated: 2010-01-30 04:05:31
    Story Summary: This contract will allow Coriell to introduce a powerful type of stem cell called induced pluripotent stem cells, or iPS cells, into the Repository. Produced by genetically reprogramming specialized cell types, such as skin cells, iPS cells share the ability of embryonic stem cells to turn into any of the 200 cell types [...] Related posts:Two Lines Account for Most Human Embryonic Stem Cell Research, Stanford Scholar Finds 2 lines account for most human embryonic stem cell research, Stanford scholar finds HUMAN EMBRYONIC STEM CELL RESEARCH REVEALS EARLIEST STEP IN HUMAN DEVELOPMENT

  • Research and Markets: This Essential Report on U.S. Epigenetics Markets is Now Available

    Updated: 2010-01-30 02:34:31
    : . Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags application usage conversion gene activity segments user groups Research and Markets : This Essential Report on U.S . Epigenetics Markets is Now Available Posted on 30 January 2010 02:34 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary This additional level of transcriptional regulation goes beyond genetic information stored in the DNA sequence to regulate gene activity . Thus , epigenetics is essentially the missing link between genotype and phenotype that had escaped researchers until the recent surge in epigenetic discovery . This research has deemed epigenetics important in many different fields , causing researchers to adopt epigenetic methods to see if they answer their biological questions that have not been answered through more established genomic and proteomic technologies . Epigenetic product vendors range from small vendors focusing nearly exclusively on the epigenetics market to well-established companies looking to offer complete workflows for the life sciences . The epigenetics market has become increasingly competitive

  • Cytori Issued U.S. Patent for Cell-Enriched Fat Grafting; New Patent Protects Key Cytori Market

    Updated: 2010-01-30 01:03:31
    . Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags adult commission filings financial position inherent risk international patents Cytori Issued U.S . Patent for Cell-Enriched Fat Grafting New Patent Protects Key Cytori Market Posted on 30 January 2010 01:03 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary Within the Cytori family of products , the Company markets the Celution(r 800 CRS System that creates adipose tissue-derived stem and regenerative cell-enriched autologous fat grafts , in the EU and elsewhere throughout the world . Cytori Therapeutics intellectual property portfolio currently includes 19 issued U . S . and international patents and 100 pending applications worldwide relating to the devices , methods and uses of adipose-derived stem and regenerative cells . About CytoriCytori is an emerging leader in regenerative medicine , providing patients and physicians around the world with medical technologies that harness the potential of adult regenerative cells from adipose tissue . The Celution(r System family of medical devices and instruments is being sold into the European

  • T. Denny Sanford Donates $50 Million to Burnham Institute for Medical Research

    Updated: 2010-01-29 23:32:31
    . Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags 10 million 30 million innovative therapies stem cell transformation T . Denny Sanford Donates 50 Million to Burnham Institute for Medical Research Posted on 29 January 2010 23:32 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary While Burnham has been extremely successful at winning grant support from the National Institutes of Health NIH achieving eight consecutive years of double-digit growth in grant revenue and currently ranking fourth in the nation among similar organizations , philanthropy provides funding for initiatives not typically supported by the NIH and ensures stability in an increasingly competitive grant environment . The gift will be made in 10 million increments for five years . Malin Burnham , whose own gift catalyzed a similar transformation in 1996, welcomes the change and the challenge . We are all honored by the confidence Denny Sanford has shown in the Institute , said Burnham . In less than two and a half years , Denny Sanford has invested 100 million in San Diego life-science organizations . Sanford has given

  • Babraham scientists find survival factor for keeping nerve cells healthy

    Updated: 2010-01-29 22:01:31
    Story Summary: Although the disintegration and collapse of axons is seen in many neurodegenerative diseases, the factors driving this have remained elusive. What is really exciting here is how a single, intrinsic protein affects nerve cell survival, explained Dr Coleman, a Group Leader at Babraham. It offers a new approach to treating axonal disorders by [...] Related posts:How cells tolerate DNA damage — start signal for cell survival program identified Compounds that help protect nerve cells discovered by Duke team Compounds that help protect nerve cells discovered by Duke team

  • Rejuvenating the old immune system

    Updated: 2010-01-29 20:30:31
    Story Summary: This decline in the number of fighters and the associated weakness of the immune defense may be responsible for the age-associated increase in susceptibility to infections. The HZI researchers have succeeded to enhance the resistance to an infection in aged mice by treating them with a macrophage-specific growth factor. While the young animals [...] Related posts:New culprit for viral infections among elderly — an overactive immune response Human immune cells a in mice Zc3h12a is an RNase essential for controlling immune responses by … – Nature.com (subscription)

  • Healthpoint Launches Collagenase SANTYL(R) Ointment in Canada

    Updated: 2010-01-29 18:59:31
    Story Summary: There is also wide agreement that debridement should no longer be considered a one-time event; rather, effective ongoing or maintenance debridement until granulation tissue is well established should be provided to keep the wound free of necrotic, bacterial and cellular barriers that can interfere with the wounds ability to progress toward healing. Healthpoint [...] Related posts:Applied Biosystems Launches Molecular Tools for Measuring Gene Activity in Biological Pathways Roche Launches Complete Detection Kit for Influenza A /H1N1 on LightCycler(r) System Warnex Launches Test for Influenza A H1N1 Virus | SYS-CON CANADA

  • UCF professors vaccine could be lethal weapon against malaria, cholera

    Updated: 2010-01-29 17:28:31
    , Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags clinical trials lethal weapon medicine mice plants UCF professors vaccine could be lethal weapon against malaria , cholera Posted on 29 January 2010 17:28 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary A University of Central Florida biomedical researcher has developed what promises to be the first low-cost dual vaccine against malaria and cholera . There is no FDA approved vaccine to prevent malaria , a mosquito-borne illness that kills more than 1 million people annually . Researchers gave mice freeze-dried plant cells orally or by injection containing the vaccine . Hes also successfully grown insulin in plants to find what could be a long-lasting cure for diabetes . Daniells team continues to research these vaccines and is looking for investors to help fund clinical trials . Producing vaccines in plants is less expensive than traditional methods because it requires less labor and technology , Daniell said . There is no need for expensive purification , cold storage , transportation or sterile delivery via injections . Daniell , a

  • Cold Spring Harbor Protocols Features Analysis Of Microbes, Immune Response

    Updated: 2010-01-29 15:57:31
    Story Summary: Improvements to cloning and sequencing techniques are allowing researchers to study microorganisms in environmental samples, and new knowledge of species interactions and community dynamics is emerging. The identification of microorganisms in these samples is of vital importance to interpreting the results of such studies. The method is highly sensitive, quantitative, easy to use, [...] Related posts:ChIP-Seq, Drosophila Targeted Mutagenesis Featured In Cold Spring Harbor Protocols ChIP-Seq, Drosophila Targeted Mutagenesis Featured In Cold Spring Harbor Protocols Cold Spring Harbor Protocols features RNA analysis methods

  • Strong New Evidence Links Retail Meat To Urinary Tract Infections

    Updated: 2010-01-29 14:26:31
    Story Summary: Samples taken in the Montreal area between 2005 and 2007, in collaboration with the Public Health Agency of Canada and the University of Guelph, provide strong new evidence that E. coli(Escherichia coli) bacteria originating from these food sources can cause common urinary tract infections. Eating contaminated meat or food does not directly [...] Related posts:Promising Results From A Vaccine To Prevent Urinary Tract Infections Vaccine For Urinary Tract Infections Shows Early Promise Vaccine to prevent urinary tract infections shows early promise

  • Genome Sequencing Study Finds Clues to Unraveling the Causes of Deadly Epidemics

    Updated: 2010-01-29 11:24:31
    Story Summary: This has resulted in the first precise explanation of the biological events contributing to deadly epidemics of severe infection. This method can be used to track and help prevent devastating epidemics in the future. In some cases, patients suffer from a devastating infection of tissue and muscle requiring extensive surgery. On average, each [...] Related posts:Genome sequencing study finds clues to unravelling the causes of deadly epidemics Personalized Genome Sequencing Finds Disease-Causing Genes – 3/5/09 Genome sequencing shows past genetic events made soybeans rich in versatile gene families

  • Wyatt Technology Demonstrates SEC-MALS Capabilities for Studying Interactions of Tumor Suppressor p53 with S100 Proteins

    Updated: 2010-01-29 09:23:47
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags cancer research instrumentation oligomerization peptides tumor suppressor p53 Wyatt Technology Demonstrates SEC-MALS Capabilities for Studying Interactions of Tumor Suppressor p53 with S100 Proteins Posted on 29 January 2010 09:23 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary ScienceWyatt Technology Demonstrates SEC-MALS Capabilities for Studying Interactions of Tumor Suppressor p53 with S100 Proteins2010-01-22 13:16:11 SANTA BARBARA , CALIFORNIA January 21 2010 Wyatt Technology Corporation , the world leader in instruments for absolute macromolecular characterization , announces that its light scattering system has been selected by the MRC Centre for Protein Engineering to investigate the interactions of the p53 tumor suppressor gene with S100 protein . Wyatts static Multi-Angle Light Scattering MALS systems further cancer research by studying how S100 proteins influence the oligomerization of p53 following separation by Size Exclusion Chromatography SEC However , when the p53 gene is mutated , it can no longer serve its tumor

  • Memory Loss And Alzheimers Disease: TGen-Led Team Finds 3 Proteins That Dismantle Bridges Within Brain Cells

    Updated: 2010-01-29 08:22:31
    Story Summary: It facilitates the ability of people to form new memories – to form new connections between different neurons – and maintain those memories. However, sometimes the tau protein becomes hyperphosphorylated, a condition in which the tau creates neurofibrillary tangles, one of the signature indicators of Alzheimers. Of these 26, three of them – [...] Related posts:Researchers identify proteins that might contribute to memory loss and Alzheimers disease Alzheimers Society Research Finds Link Between Infection And Memory Loss Infections May Lead To Faster Memory Loss In Alzheimers Disease

  • New gene involved in autophagy — the cellular recycling program

    Updated: 2010-01-29 06:51:31
    Story Summary: For example, several studies demonstrate that some neurodegenerative diseases caused by the abnormal aggregation of proteins, such as Huntingtons disease, are associated with reduced autophagy. However, further knowledge about this pathway and its components are required as well as a complete understanding of the precise role of autophagy in each disease in order [...] Related posts:Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy – 7thSpace Interactive HIV uses autophagy for its own means HIV Uses Autophagy For Its Own Means

  • Gene essential for neuron development and contextual memory

    Updated: 2010-01-29 05:20:31
    Story Summary: Gene Essential for Neuron Development and Contextual Memory A team of researchers of CNR-LUMSA-S. Lucia demonstrates the essential function of the gene PC3/Tis21 (BTG2) in the maturation of the neuron, and how this plays an important role in the integration of the neuron into memory circuits. In fact, the neuroscientists coordinated by Dr. [...] Related posts:Oprah neuron hints at nature of memory Can a Single Neuron Tell Halle Berry From Grandma Esther? | Memory, Emotions, & Decisions | DISCOVER Magazine Teasing Apart Brain Function, Neuron by Neuron

  • Approval of Genetically Engineered Food Crop in India Spurs Nationwide Protest

    Updated: 2010-01-29 05:01:24
    (Beyond Pesticides, January 29, 2010) A genetically engineered (GE) variety of brinjal, or eggplant, was approved by India’s Genetic Engineering Approval Committee (GEAC) last October. As the central government decides on approval of the crop’s commercial release, farmers, environmentalists, doctors, and even several state governments have mobilized in protest. India has already approved the commercial [...]

  • Rare genetic variants create synthetic genome-wide signals of disease risk

    Updated: 2010-01-29 03:49:31
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags extremes gene variants simulation studies statistics trees Rare genetic variants create synthetic genome-wide signals of disease risk Posted on 29 January 2010 03:49 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary The finding appearing in PLoS Biology,stems from a series of simulation studies , and challenges common interpretations of a multitude of genome-wide association studies GWAS that have identified thousands of single-DNA letter changes associated with greater risk of common diseases such as cancer , heart disease and diabetes . It may also hold important implications for understanding the underlying architecture of human disease . Goldstein has long argued that rare , more powerful genetic variation lies in more remote stretches of the genome that GWA studies dont cover . D . a bioinformatician in the IGSP , simulated case-control studies with sample sizes between 2,000 and 6,000 subjects by using simulated genealogical trees to create a realistic spread of variants across one section of a chromosome . They then used statistics

  • Protein may be new target for obesity, diabetes therapies

    Updated: 2010-01-29 02:33:47
    Story Summary: A little bit of stress might be just what the doctor ordered to combat obesity and diabetes. A new study in mice finds that a protein that plays a role in responding to certain kinds of stress may help regulate a metabolic pathway important for controlling blood sugar, burning fat and even making [...] Related posts:Lack of cellular enzyme triggers switch in glucose processing Inner workings of molecular thermostat point to pathways to fight diabetes, obesity Scarring key to link between obesity and diabetes

  • 2-pronged immune response offers hope for effective Salmonella vaccine

    Updated: 2010-01-29 02:18:31
    Story Summary: Dr MacLennan and colleagues also identified protective Salmonella-specific antibodies that develop in African children within the first two years of life, the period in which the majority of NTS-related cases of bacteraemia occur. Young children who have yet to encounter these bacteria lack the antibodies and are at greatest risk from infection. Our [...] Related posts:Chicken pox vaccine reduces shingles risk in kids – study of 172,000 kids used EHRs New findings suggest strategy to help generate HIV-neutralising antibodies On your last nerve: NC State researchers advance understanding of stem cells

  • Gastric Ulcer Bacteria Turn Immune Defence Inwards

    Updated: 2010-01-29 00:55:31
    Story Summary: When an immune response is initiated a specific type of cell migrates to the lymph nodes to activate new immune cells, telling them where they need to go to tackle the infection. Many of the cells that ought to collect more new immune cells stop at these accumulations and begin activating these instead, [...] Related posts:A potent and selective anti-tumor agent on human gastric adenocarcinoma Herb medicine Rocket has gastric anti-ulcer properties – Health – Health & Science – The Times of India Tummy troubles — gastrin key in bacterial-induced stomach cancer

  • Illuminating protein networks in 1 step

    Updated: 2010-01-29 00:47:31
    Story Summary: A protein is then targeted by an antibody, allowing scientists to measure the amount present in the cells. When you walk into a dark room and dont have much information, its difficult to predict where everything is going to be, Jones said. If someone can simply turn on the light, you dont have [...] Related posts:Illuminating protein networks in one step One Step Closer to Closure-12/23/09 Bioinformatic reconstruction of global networks provides shortcuts to protein functions

  • JCI table of contents: Jan. 25, 2010

    Updated: 2010-01-28 23:16:31
    Story Summary: Adjuvants are most commonly used to increase the magnitude of vaccine-induced immune responses, specifically T cell immune responses. However, the quality of a T cell response can be more important than its quantity, and a team of researchers, at the National Institutes of Health, has now identified a way to increase the quality [...] Related posts:JCI table of contents: July 20, 2009 JCI online early table of contents: Sept. 1, 2009 JCI online early table of contents: Sept. 1, 2009

  • Vaccine Approach Extends Life of Metastatic Prostate Cancer Patients

    Updated: 2010-01-28 21:45:31
    Story Summary: Patients tolerated the vaccine well; only a small number experienced side effects such as fatigue, fevers, and nausea. Although this study is relatively small, it offers encouraging evidence of a clinically meaningful benefit from this vaccine approach, says principal investigator and lead author Philip Kantoff, MD, of Dana-Farber, who helped design the trial. [...] Related posts:Study Reveals A Reprogrammed Role For The Androgen Receptor In Androgen-Independent Prostate Cancer Key Event In Prostate Cancer Progression Discovered By Scientists Genes Linked to Breast Cancer Drug Resistance Could Guide Future Treatment

  • St. Jude and Washington University team to unravel genetic basis of childhood cancers

    Updated: 2010-01-28 20:14:31
    Story Summary: Jude Childrens Research Hospital and Washington University School of Medicine in St. Louis, today announced an unprecedented effort to identify the genetic changes that give rise to some of the worlds deadliest childhood cancers. We are on the threshold of a revolution in our understanding of the origins of cancer. The collaboration [...] Related posts:University Of Washington Receives $25 Million To Create Northwest Genomics Center Chicago Cancer Genome Project studies genetics of 1,000 tumors University of Florida News – Genetic finding could lead to targeted therapy for neuroblastoma

  • Brain protein critical to movement, memory, and learning deciphered at the Advanced Light Source

    Updated: 2010-01-28 19:43:47
    Story Summary: 1/24/2010 9:16:02 PMBrain protein critical to movement, memory, and learning deciphered at the Advanced Light SourceThe structure of a protein that is sending electrical pulses between neurons in your brain as you read this article has been fully mapped for the first time using Lawrence Berkeley National Laboratorys Advanced Light Source. This is [...] Related posts:Jet-Propelled Imaging For An Ultrafast Light Source Protein structures revealed at record pace Protein structures revealed at record pace

  • Study of Shark Virgin Birth Shows Offspring Can Survive Long Term

    Updated: 2010-01-28 18:43:31
    Story Summary: These findings are remarkable because they tell us that some female sharks can produce litters of offspring without ever having mated with a male. Although the shark mother was kept in a tank at the Belle Isle Aquarium in Detroit where only another female of a different but related species resided, genetic testing [...] Related posts:Parthenogenesis: When Animals Reproduce Without a Mate Study: Love at first sight might be genetic iTWire – Male birth control pill closer with CATSPER1

  • Researchers correct the record about behavior of important human protein tied to cancer

    Updated: 2010-01-28 17:12:31
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags assistant professor conclusion external cues import proteins lenormand Researchers correct the record about behavior of important human protein tied to cancer Posted on 28 January 2010 17:12 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary The body is made up of cells that communicate with each other and with external cues via receptors at their surfaces . To generate cellular responses , signaling pathways are activated that initiate movement of proteins to specific locations inside the cells , notably the nucleus , where DNA is situated , said Diane Lidke , assistant professor at the University of New Mexico School of Medicines department of pathology and lead author on the paper to be published Jan . 29 in the Journal of Biological Chemistry . ERKs entry in the nucleus is unconventional , because the protein lacks the ability to bind to the known nuclear import proteins , Lidke said . The entry in the nucleus of the mutant and the exchange in and out of the nucleus were slower than normal ERK , which could explain why the 1998

  • NIGMS awards contract to expand human genetic cell repository

    Updated: 2010-01-28 15:41:31
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags clinical characteristics genomic research new contract prevention u s department NIGMS awards contract to expand human genetic cell repository Posted on 28 January 2010 15:41 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary While not derived from embryos , iPS cells offer the same scientifically desirable properties as embryonic stem cells . The iPS cells will be available to researchers in about six months . Established by NIGMS in 1972, the HGCR provides human cell lines and DNA for use in genetic and genomic research . Scientists use the cells and DNA to identify genes and biochemical changes associated with a wide range of conditions and to study rare genetic diseases . The largest part of the repository is the inherited disease collection , which represents more than 1,000 disorders . To aid understanding of human genetic variation , the HGCR collection also includes cell lines and DNA samples from populations around the world and from several ethnic groups within the United States . Under the new contract , the HGCR will also begin

  • Thinking outside the block in disease gene studies

    Updated: 2010-01-28 14:10:31
    Story Summary: A new study suggests that researchers may need to broaden their search farther afield to pinpoint rare but powerful disease-causing mutations. Researchers from two large genome research centers at The Childrens Hospital of Philadelphia and at Duke University published a study today in the online journal Public Library of Science Biology (PLoS Biology), [...] Related posts:Rare genetic variants create synthetic genome-wide signals of disease risk NEJM — Genomewide Association Studies and Human Disease Experts scan disease links with Chinese gene map

  • Drugs May Shut Down Several Epstein-Barr Virus-Induced Diseases

    Updated: 2010-01-28 11:08:31
    Story Summary: Most of her work has focused on the form of EBV that actively produces infection, but recently she turned to the so-called latent form. Latently infected cells express transforming viral proteins that can change normal cells into cancer cells. One key viral protein, EBNA-1, is required for EBV to live long-term in host [...] Related posts:Key mechanism for the proliferation of Epstein-Barr virus discovered Key Mechanism For The Proliferation Of Epstein Barr Virus Discovered Epstein-Barr Virus Linked to MS

  • Study: New vaccine delivery system may be more effective

    Updated: 2010-01-28 09:37:31
    Story Summary: Now, an interdisciplinary team of Cornell researchers has devised a new way to make vaccines that promises to prevent diseases much more cheaply. The new technique, described online in the journal Proceedings of the National Academy of Sciences, which involves fusing a novel component to the vaccine to boost its effectiveness, can effectively [...] Related posts:New vaccine delivery may be more effective against measles MDRNA, Inc. Reports Effective Local Delivery of a UsiRNA in an In Vivo Model of Bladder Cancer A global breakthrough in the study of a protein linked to the spread of viruses

  • Genome sequence of the palaeopolyploid soybean

    Updated: 2010-01-28 09:28:47
    Story Summary: 0/), which permits distribution, and reproduction in any medium, provided the original author and source are credited. We predict 46,430 protein-coding genes, 70% more than Arabidopsisand similar to the poplar genome which, like soybean, is an ancient polyploid (palaeopolyploid). About 78% of the predicted genes occur in chromosome ends, which comprise less than [...] Related posts:Mapping and sequencing of soybean genome paves the way for improved soybean crops Soybean genome turns out to be soysoybeanbean Scientists sequence soybean genome, reveal pathways for improving biodiesel

  • Transcriptional role of cyclin D1 in development revealed by a geneticaproteomic screen

    Updated: 2010-01-28 06:03:47
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags ablation acetylation protein proteomic Transcriptional role of cyclin D1 in development revealed by a geneticaproteomic screen Posted on 28 January 2010 06:03 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary AccessTo read this story in full you will need to login or make a payment see right Genetic ablation of cyclinD1 resulted in decreased CBP recruitment , decreased histone acetylation of the Notch1promoter region , and led to decreased levels of the Notch1 transcript and protein in cyclinD1-null Ccnd1- retinas . Our approach , which we term genetic-proteomic , can be used to study the in vivofunction of essentially any protein . To read this story in full you will need to login or make a payment see right I want to purchase this articlePrice : US$32In order to purchase this article you must be a registered user Read the Full Story VN:F 1.8.1_1037 Rating : 0 from 0 votes Related : posts Access Irreversibility of mitotic exit is the consequence of systems-level feedback Nature Access A hub-and-spoke circuit drives pheromone attraction

  • Gene family found to play key role in early stages of development

    Updated: 2010-01-28 00:39:31
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags cell polarity cilia cilias key role mutant embryos Gene family found to play key role in early stages of development Posted on 28 January 2010 12:39 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary This unique placement , coupled with the cilias clockwise circular beating motion , results in the leftward flow and , subsequently , the embryos left-right symmetry breaking . Hamada and Wynshaw-Boris decided to look at whether a specific gene family , called the Dishevelled gene family , might be directing the cilias migration to the back side of the node cells . Having researched this gene family for many years , the Wynshaw-Boris lab developed mouse models with each of the three Dishevelled genes turned off to study their individual functions . In doing so , they found that the Dishevelled genes activate a genetic pathway , called the planar cell polarity pathway , which helps determine positional information in cells and tissues . In the very earliest stages before left-right symmetry breaking occurred cilia were located in the center of

  • Fluidigm and IntegraGen Join Forces to Create a Genetic Analysis Service and European Demonstration Lab

    Updated: 2010-01-27 23:13:47
    Story Summary: Breaking News Jan 25 2010, 3:03 AM ESTFluidigm and IntegraGen Join Forces to Create a Genetic Analysis Service and European Demonstration LabBusiness WireFluidigm, the inventor of integrated fluidic circuits (IFCs), has joined with IntegraGen SA, one of Franceas leading providers of genetic research testing services, to bring IFC technology to French researchers. About [...] Related posts:FLUIDIGM AND UNISCIENCE JOIN FORCES IN BRAZILIAN DISTRIBUTION DEAL Undergraduate Research Organizations Join Forces Fluorophores join forces for cell imaging

  • New Compounds May Control Deadly Fungal Infections

    Updated: 2010-01-27 19:48:47
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags capabilities drugs medical information syracuse university viral infection New Compounds May Control Deadly Fungal Infections Posted on 27 January 2010 19:48 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary The fungi can also form biofilms that attach to surfaces and are up to 1,000 times more resistant to anti-fungals . Ren and his collaborator , chemistry professor Yan-Yeung Luk of SUs College of Arts and Sciences , have filed a non-provisional patent application . This stimulated a strong demand for more effective drugs and led to the successful research at Syracuse . The researchers genomic study suggests that furanones have different genetic targets than current anti-fungal agents and thus may avoid drug resistance acquired in the past . Ongoing furanones research at Syracuse University will investigate a broad spectrum of other potential capabilities , ranging from diverse medical uses , such as controlling bacterial and fungal biofilms , to anti-fungal wood preservatives for the building materials market . Source:Sara MilerSyracuse

  • Ebolas Deadly Secret Discovered By Iowa State University Researcher

    Updated: 2010-01-27 17:34:13
    Story Summary: A research team led by Gaya Amarasinghe, an assistant professor of biochemistry, biophysics and molecular biology, had previously solved the structure of a critical part of an Ebola protein known as VP35, which is involved in host immune suppression. Amarasinghe and his research team now know how VP35 is able to do it. [...] Related posts:Iowa State University researcher discovers Ebolas deadly secret Iowa State University researcher discovers key to vital DNA, protein interaction Iowa State University researcher develops vaccine for H1N1 flu virus in swine – insciences

  • How Clean Is Your Knife?

    Updated: 2010-01-27 16:23:47
    Story Summary: Researchers from the Robert Koch Institute in Berlin, Germany have optimised a rapid-acting, practical formula for disinfecting surgical instruments. They are a particular problem to eliminate because they are very resistant to inactivation and can even become fixed on surfaces by some conventional disinfectants. Disinfectants are the first line of defence against the [...] Related posts:Test helps in fight against lung infections and for treating other life-threatening infections Disinfectants may promote growth of superbugs New Compounds May Control Deadly Fungal Infections

  • 1918 And 2009 H1N1 Flu Probably Not Spread By Birds

    Updated: 2010-01-27 09:33:47
    Story Summary: The origin of the 1918 H1N1 virus is unknown and despite its genetic similarity to avian influenzas, the results of this study show it is unlikely to have jumped the species barrier from chickens to humans. If flu viruses are passed back and forth between hosts (e. g. through close human contact [...] Related posts:H1N1 traced to 1918 pandemic H1N1 traced to 1918 pandemic H1N1 influenza adopted novel strategy to move from birds to humans

  • Virus Replication Seen On Video Is Faster Than Thought Possible

    Updated: 2010-01-27 08:34:13
    Story Summary: Previously, viruses were thought to spread by entering a cell, replicating there, and then being released to infect new cells, so that the rate of spread of a virus would be limited by how quickly it could replicate in each cell. However, a virus called vaccinia spreads in a different and much faster [...] Related posts:Video of virus in action shows viruses can spread faster than thought possible Visualizing Virus Replication In Three Dimensions New strategy for inhibiting virus replication

  • The Noisiest Neurons Persist In The Adult Brain

    Updated: 2010-01-27 06:08:47
    Story Summary: Current therapies have hit a roadblock because the vast majority of grafted cells do not survive and do not integrate into adult brain circuits. Our work suggests that any perturbation that increases the activity of neurons will enhance the likelihood of their survival. An important technological advance, the methods used in this study [...] Related posts:Noisiest neurons persist in the adult brain MIT Neuroengineers Silence Brain Cells With Multiple Colors Of Light — New Tools Show Potential For Treating Brain Disorders Key To Developing Auditory Neurons Found

  • Researchers trace effects of genetic defect in myotonic muscular dystrophy

    Updated: 2010-01-27 02:43:47
    Story Summary: A study published in Nature Structural & Molecular Biologyshows that the loss of a single protein accounts for most of the molecular abnormalities associated with the disease, while loss of a second protein also seems to play an important role. Each of the affected proteins interacts with an array of genes that are [...] Related posts:Genetic source of muscular dystrophy neutralized Genetic source of muscular dystrophy neutralized Genetic source of muscular dystrophy neutralized

  • Genomic Surveillance Of Pandemic H1N1

    Updated: 2010-01-27 00:58:47
    Story Summary: While we are not expecting a third wave of H1N1 in BC, we will have over 250,000 visitors in Vancouver in February, which may impact influenza virus evolution. Large-scale genome projects such as this have only become common in the last five years, as sequencing technologies have improved and become faster and more [...] Related posts:Virulence Of Pandemic H1N1 Virus: K-State Study 1918 And 2009 H1N1 Flu Probably Not Spread By Birds Decoding The Genomic Sequences Of H1N1 Using Isolates From Outbreak In Argentina

  • Scientists shed new light on walking

    Updated: 2010-01-26 23:34:13
    Story Summary: Shining blue light on brainstems or spinal cords isolated from these mice produces walking-like motor activity. The findings, which are published in the scientific journal Nature Neuroscience, are of potential significance to the recovery of walking after spinal cord injury. In order to test the hypothesis that activation of excitatory neurons is essential [...] Related posts:Photoswitches shed light on burst swimming in zebrafish Photoswitches shed light on spontaneous free swimming in zebrafish Pot shot: Scientists find cannabis trigger for forgetfulness

  • Genes Linked to Breast Cancer Drug Resistance Could Guide Future Treatment

    Updated: 2010-01-26 23:18:47
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags adjuvant chemotherapy breast tumors chromosome 8 drug therapy high risk Genes Linked to Breast Cancer Drug Resistance Could Guide Future Treatment Posted on 26 January 2010 23:18 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary Newswise Researchers at Dana-Farber Cancer Institute have discovered a gene activity signature that predicts a high risk of cancer recurrence in certain breast tumors that have been treated with commonly used chemotherapy drugs . The investigators from the Dana-Farber Womens Cancers Program undertook the studies to search for molecular traits in tumors that cause some patients to suffer recurrences in the wake of breast cancer surgery despite post-surgery , or adjuvant , chemotherapy , while other patients do well for many years . The scientists probed stored breast tumor specimens from 85 patients and found the gene signature associated with drug resistance in about 1 in 5 samples , according to the report . These results suggest that tumors resistant to anthracyclines may still be sensitive to other agents , said

  • Illuminating protein networks in one step

    Updated: 2010-01-26 19:53:47
    Story Summary: Illuminating protein networks in one stepA new assay capable of examining hundreds of proteins at once and enabling new experiments that could dramatically change our understanding of cancer and other diseases has been invented by a team of University of Chicago scientists. Since the 1970s, laboratories have used Western blots to measure proteins. [...] Related posts:Illuminating protein networks in 1 step Bioinformatic reconstruction of global networks provides shortcuts to protein functions Carnegie Mellons Philip LeDuc discovers new protein function

  • Study shows genital herpes virus reactivates widely throughout genital tract

    Updated: 2010-01-26 16:28:47
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags colleagues lesion pathogenesis serological testing sex partners Study shows genital herpes virus reactivates widely throughout genital tract Posted on 26 January 2010 16:28 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary A new study , however , finds that the virus can frequently reactivate throughout the genital tract , an important new concept that could help guide both HSV-2 treatment and prevention . In the study , Christine Johnston , MD , MPH , and colleagues at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle collected daily samples during a 30-day period from seven separate genital sites in four women infected with HSV-2. Additionally , although there were a high proportion of days with lesions during the study period , two of the participants who had recently acquired genital herpes contributed the majority of lesion days . Many clinicians treat patients with newly diagnosed herpes episodically , managing the signs and symptoms of periodic symptomatic recurrences , Dr . Hook wrote . From a

  • Study shows genital herpes virus reactivates widely throughout genital tract

    Updated: 2010-01-26 14:34:13
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags colleagues lesion pathogenesis serological testing sex partners Study shows genital herpes virus reactivates widely throughout genital tract Posted on 26 January 2010 14:34 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary A new study , however , finds that the virus can frequently reactivate throughout the genital tract , an important new concept that could help guide both HSV-2 treatment and prevention . In the study , Christine Johnston , MD , MPH , and colleagues at the University of Washington and the Fred Hutchinson Cancer Research Center in Seattle collected daily samples during a 30-day period from seven separate genital sites in four women infected with HSV-2. Additionally , although there were a high proportion of days with lesions during the study period , two of the participants who had recently acquired genital herpes contributed the majority of lesion days . Many clinicians treat patients with newly diagnosed herpes episodically , managing the signs and symptoms of periodic symptomatic recurrences , Dr . Hook wrote . From a

  • Study predicts HIV drug resistance will surge

    Updated: 2010-01-26 13:03:47
    Story Summary: These strains could prove disastrous by hindering control of the HIV pandemic. In a study published Jan. 14 on the website of the journal Science, researchers from the Semel Institute for Neuroscience and Human Behavior at UCLA and the University of California, San Franciscos HIV AIDS Program at San Francisco General Hospital, [...] Related posts:Study predicts HIV drug resistance will surge New research strategy for understanding drug resistance in leukemia Genes Linked to Breast Cancer Drug Resistance Could Guide Future Treatment

  • Cancer Vaccines a Drug Pipeline Analysis and Market Forecasts to 2016

    Updated: 2010-01-26 09:38:29
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags future market market drivers market forecasts molecules restraints Cancer Vaccines a Drug Pipeline Analysis and Market Forecasts to 2016 Posted on 26 January 2010 09:38 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary There are currently two products , which constitute the global cancer vaccines market . From the market perspective , there are going to be multiple launches of vaccines between 2010 and 2013-14, which would substantially increase the market size and growth . aspx ID=Cancer-Vaccin The present global cancer vaccines market is occupied by cervical cancer vaccines . The launch of these prophylactic vaccines has renewed interest in the development of vaccines for cancer . Though the therapeutic vaccines were in the pipeline for a long period , none of them has managed to cross the regulatory hurdles and receive approval in the decisive US and EU markets . Manufacturers have faced trouble proving the efficacy and safety of these vaccines along with demanding manufacturing guidelines . The market has fewer options for prevention

  • Subtle changes in immune system soon after HIV infection show who may benefit from earlier treatment

    Updated: 2010-01-26 06:46:29
    Story Summary: However, there is still uncertainty about the best time to initiate antiretroviral therapy, and identifying patients most likely to benefit from earlier initiation of treatment could help reduce levels of HIV-related illness and death. They also assessed the role of immune activation, levels of naive CD4 and CD8 cells, and levels of cell-associated [...] Related posts:Focusing HIV treatment helps control concurrent hepatitis B infection Contact tracing successful at diagnosing HIV in partners of those with acute infection Phambili trial of Merck vaccine shows post-infection benefit in women

  • Study predicts HIV drug resistance will surge

    Updated: 2010-01-26 05:34:13
    Story Summary: These strains could prove disastrous by hindering control of the HIV pandemic. In a study published Jan. 14 on the website of the journal Science, researchers from the Semel Institute for Neuroscience and Human Behavior at UCLA and the University of California, San Franciscos HIV AIDS Program at San Francisco General Hospital, [...] Related posts:Study predicts HIV drug resistance will surge New research strategy for understanding drug resistance in leukemia Genes Linked to Breast Cancer Drug Resistance Could Guide Future Treatment

  • MRSA bacteria mutates quickly as it spreads

    Updated: 2010-01-26 01:02:29
    Story Summary: All the isolates are variations of a MRSA strain known as sequence type 239, or ST239. Recently developed DNA-decoding technology known as high-throughput sequencing drastically reduces the time and cost of deciphering a genome. The first bacterial genome in 1995, for instance, took three years and millions of dollars to decode. Now researchers [...] Related posts:Tracking MRSA Evolution And Transmission MRSA strain linked to high death rates New, virulent strain of MRSA poses renewed antibiotic resistance concerns

  • Simple steps prevent life-threatening bloodstream infections in children

    Updated: 2010-01-26 00:30:29
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags adult patients blood vessel groin hand washing routine care Simple steps prevent life-threatening bloodstream infections in children Posted on 26 January 2010 12:30 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary Results are to be published in the February issue of the journal Pediatrics . A central venous catheter , or central line , is a tube inserted into a major blood vessel in the neck , chest or groin to serve as a temporary portal for injected medications and fluids , or blood sampling in patients who need them frequently . Therefore , investigators say , simple precautions like regularly changing the dressing covering the central line , changing the tubes and caps attached to it , cleaning the line before and after use , and rigorous hand washing before handling the line are essential to keeping bacteria away . The new research also showed that while proper placement and daily care were both important in reducing catheter-related bloodstream infections , proper daily maintenance played the greatest role in preventing infections

  • High-resolution gene technique zooms in on superbug

    Updated: 2010-01-25 22:10:29
    Story Summary: The success of the new method relies on comparing whole genetic codes, the scientists said. One set of 42 was taken from hospitals in North and South America, Europe, Australia and Asia from patients who became infected with MRSA between 1982 and 2003, and 20 were from a hospital in Thailand, from patients [...] Related posts:Tracking MRSA Evolution And Transmission NZ scientist helps in superbug battle – Health – NZ Herald News Tracking a Superbug with Whole-Genome Sequencing

  • Blog – Genetics Doesnt Help Predict Diabetes Risk

    Updated: 2010-01-25 16:26:29
    Story Summary: Companies including 23andMe and Navigenics have marketed genetic tests to assess risk of type 2 diabetes and other diseases with the idea that this information can help people try to prevent diseases for which they are genetically at risk. When they looked specifically at factors affecting type 2 diabetes risk, they found that [...] Related posts:Diabetic flies: Fruit fly model helps unravel genetics of human diabetes Fruit Fly Model Created To Help Unravel Genetics Of Human Diabetes UM scientists create fruit fly model to help unravel genetics of human diabetes

  • Tracking a Superbug with Whole-Genome Sequencing

    Updated: 2010-01-25 13:34:29
    Story Summary: But for some people, the microbes can cause severe problems, including serious skin infections, sepsis, and death. The researchers constructed an evolutionary tree for the microbes and confirmed that MRSA likely first emerged in Europe in the 1960s, coinciding with the growing use of antibiotics to treat staph infections. The tree also showed [...] Related posts:High-resolution gene technique zooms in on superbug Tracking MRSA Evolution And Transmission A new superbug found in Britain is major concern: Government scientists

  • Simple steps prevent life-threatening bloodstream infections in children

    Updated: 2010-01-25 11:34:13
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags adult patients blood vessel groin hand washing routine care Simple steps prevent life-threatening bloodstream infections in children Posted on 25 January 2010 11:34 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary Results are to be published in the February issue of the journal Pediatrics . A central venous catheter , or central line , is a tube inserted into a major blood vessel in the neck , chest or groin to serve as a temporary portal for injected medications and fluids , or blood sampling in patients who need them frequently . Therefore , investigators say , simple precautions like regularly changing the dressing covering the central line , changing the tubes and caps attached to it , cleaning the line before and after use , and rigorous hand washing before handling the line are essential to keeping bacteria away . The new research also showed that while proper placement and daily care were both important in reducing catheter-related bloodstream infections , proper daily maintenance played the greatest role in preventing infections

  • Sunflower DNA map could produce plants for fuel

    Updated: 2010-01-25 10:42:29
    Story Summary: Its goal is to locate genes responsible for agriculturally important traits such as seed oil content, flowering, drought and pest tolerance. Riesebergs work with co-investigator Steve Knapp from the University of Georgia has already been helpful to the industry, said Larry Kleingartner, executive director of the Mandan, N. D. -based National Sunflower Association. [...] Related posts:Sunflower Genome Could Help Sustainable Agriculture Chemists engineer plants to produce new compounds Sunflower genome holds the promise of sustainable agriculture

  • Double trouble: Bacterial super-infection after the flu

    Updated: 2010-01-25 07:50:29
    Story Summary: However, during influenza pandemics, mortality may be significant in previously healthy young adults. Furthermore, reports of infection with antibiotic-resistant strains have been increasing in recent years. To explore the mechanisms governing the increased pathogenesis of flu upon super-infection, a group led by Dr. Sally R. Sarawar of the Torrey Pines Institute [...] Related posts:Researchers capture bacterial infection on film Stress signals link pre-existing sickness with susceptibility to bacterial infection Stress signals link pre-existing sickness with susceptibility to bacterial infection

  • GE Alfalfa Case to be Heard by U.S. Supreme Court

    Updated: 2010-01-25 05:28:29
    (Beyond Pesticides, January 25, 2010) For the first time, a case involving a genetically engineered crop will be heard by the U.S. Supreme Court. The case, Monsanto v. Geerston Seed Farms, is the most recent development in an ongoing battle to stop the use of genetically modified alfalfa seed. The seed is modified to be [...]

  • Pathway Genomics Conversation Starter #2: Why Do Genetic Testing?

    Updated: 2010-01-25 04:58:29
    : Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags conversation starter genetic health genetic variations genotyping services health Pathway Genomics Conversation Starter 2 : Why Do Genetic Testing Posted on 25 January 2010 04:58 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary The truth is , DNA testing has been put to very beneficial use for decades , primarily in the medical , law enforcement , and legal fields . By testing for common genetic variations or changes in your DNA , commonly referred to as single nucleotide polymorphisms or SNPs pronounced : snips consumers can understand more about their personal biology , and take more proactive control of their health and wellbeing . On Pathway Genomics blog , DNAction : Your Pathway to Human Genomics blog . com we discuss in more detail the information a person can learn from both a genetic health and ancestry report . com to read DNA Conversation Starter 1 : What is Genetic Testing If you are curious about what you can learn from genetic testing , look forward to Pathways next DNA Conversation Starter . About Pathway GenomicsLocated

  • New centre of excellence for research into fertility and reproduction

    Updated: 2010-01-25 02:34:13
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags downs syndrome fundamental causes infertility ovaries premises New centre of excellence for research into fertility and reproduction Posted on 25 January 2010 02:34 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary Although many of these will become pregnant naturally given time , a significant minority will not . We expect this concentration of research excellence will lead to further advances that will benefit even more couples in the future . Dr Enda McVeighThe move from premises at the Womens Centre of the John Radcliffe Hospital , which were getting increasingly cramped , means Oxford Fertility Unit now has significantly more space . Importantly , couples no longer have to walk through the maternity unit of the hospital to reach the Unit . In-vitro maturation IVM is an increasingly effective alternative to IVF , particularly for women with polycystic ovaries . Their research ranges from understanding fundamental causes of infertility , identifying factors that control how embryos implant in the womb , and research with new stem cell

  • Identification Of Potential New Class Of Drugs To Combat Hepatitis C

    Updated: 2010-01-25 02:06:29
    Story Summary: And designing a new antiviral agent is difficult, because a virus thrives by commandeering a host cells own essential functions. But they differ from mammalian cells in ways that make it feasible for them to be attacked with drugs that mostly leave our own cells alone. Antibiotics, which fight bacterial infections, have revolutionized [...] Related posts:Potential new class of drugs to combat hepatitis C identified by Stanford scientists Eiger BioPharmaceuticals Announces Identification of a Novel Class of HCV Inhibitors Study finds potential way to make an AIDS vaccine

  • Unwanted guests: How herpes simplex virus gets rid of the cells security guards

    Updated: 2010-01-24 23:14:29
    Story Summary: Unwanted guests: How herpes simplex virus gets rid of the cells security guardsA viral infection is like an uninvited, tenacious houseguest in the cell, using a range of tricks to prevent its eviction. Researchers at the Salk Institute for Biological Studies have identified one of the key proteins allowing herpes simplex virus (HSV) [...] Related posts:Discovery Of Protein That Reactivates Herpes Simplex Virus Helps Solve Medical Mystery Condoms associated with moderate protection against herpes simplex virus 2 Cellular process to fight herpes virus identified – Thaindian.com

  • Johns Hopkins Researchers Awarded $8 Million For HIV Research

    Updated: 2010-01-24 20:22:29
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags aids best time earthquake health care hiv research Johns Hopkins Researchers Awarded 8 Million For HIV Research Posted on 24 January 2010 20:22 by Alfie VN:F 1.8.1_1037 please wait . Rating : 5.0 5 1 vote cast Story : Summary HAART is not a solution to the AIDS epidemic it is only a step towards eradication , says Robert Siliciano , M . D . Ph . Because viral reservoirs are difficult to study in people , the team already has developed an SIV model of HAART therapy in HIV-infected people that combines four drugs and reduces viral load in the bloodstream and spinal fluid to undetectable levels . Using this model , they plan to pinpoint the best time to start HAART treatment to protect the immune system and the central nervous system from virus-induced damage , and to what degree the virus or HAART therapy causes damage to the peripheral nervous system . They also plan to figure out if its possible to rid tissues of residual virus using new drug therapies . SourceJohns Hopkins MedicineAny medical information published on this website is not intended as a substitute for

  • Molecular Genetics Core Facility at Childrens Hospital Boston Selects HybSelect from febit for Targeted Resequencing

    Updated: 2010-01-24 16:07:27
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags bioanalytical services conjunction genomics high performance sequencers Molecular Genetics Core Facility at Childrens Hospital Boston Selects HybSelect from febit for Targeted Resequencing Posted on 24 January 2010 16:07 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary In January the core facility will be receiving the Geniom RT Analyzer(r from febit to perform HybSelect . We feel that febits HybSelect technology will be a powerful tool for our researchers , in conjunction with our Applied Biosystems SOLiD platform , at a reasonable cost , said Hal Schneider , Core Manager of the MGCF . Peer Staehler , CSO at febit , said : Targeted enrichment and multiplexing are necessary to truly benefit from the advantages of high performance sequencers , and febit has developed HybSelect to meet this need . This will enable sequencing of 2,304 samples in six working days . About febit febit develops , produces and markets flexible automated solutions for enabling biochip applications in Life Sciences . febits product portfolio includes various

  • Eiger BioPharmaceuticals Announces Identification of a Novel Class of HCV Inhibitors

    Updated: 2010-01-24 14:54:27
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags aids clinical stage lipid vesicles target therapeutic agents Eiger BioPharmaceuticals Announces Identification of a Novel Class of HCV Inhibitors Posted on 24 January 2010 14:54 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary Published in the January 20th edition of Science and Translational Medicine , the research validates a domain , termed 4BAH2, within the non-structural protein NS4B of the HCV genome , as essential for HCV replication and describes the development of a high-throughput screen leading to the identification of small molecule inhibitors of 4BAH2. This is of particular benefit because , like AIDS and tuberculosis , future effective therapy for HCV is expected to require a cocktail of several independent classes of drugs , each designed against a different viral target . I am particularly excited to be working with the Eiger team because they have proven their ability to rapidly develop potent derivatives of the initial compounds described in my lab , and to efficiently move leads to the clinic . About 4BAH2 Representing

  • Video of virus in action shows viruses can spread faster than thought possible

    Updated: 2010-01-24 14:38:29
    Story Summary: When further virus particles reach the infected cell, these proteins cause the host cell to push out snake-like projections called actin tails, which drive the virus particles away towards other cells that they can infect. The researchers believe that other viruses also employ rapid spreading mechanisms. For instance, herpes simplex virus (HSV-1), which [...] Related posts:Virus Replication Seen On Video Is Faster Than Thought Possible Earlier Flu Viruses Provided Some Immunity To Current H1N1 Influenza, Study Shows A global breakthrough in the study of a protein linked to the spread of viruses

  • Sinovac Announces Plan to Launch Offering of Common Shares

    Updated: 2010-01-24 13:41:27
    Story Summary: Copies of the preliminary prospectus supplement and the accompanying prospectus may be obtained from UBS Securities LLC, Attention: Prospectus Department, 299 Park Avenue, New York, NY 10171, U. S. A. , telephone: 1-877-827- 6444 ext. Sinovacs vaccine products include Healive(R) (hepatitis A), Bilive(R) (combined hepatitis A and B), and Anflu(R) (influenza). 1(TM), Sinovacs [...] Related posts:Sinovac Receives Certificate of Approval to Distribute Panflu (H5N1) Vaccine in Hong Kong Sinovac Receives Chinas First Influenza A (H1N1) Vaccine Order Sinovac Obtains Third H1N1 Vaccine Order from Chinese Central Government

  • Tracking MRSA Evolution And Transmission

    Updated: 2010-01-24 11:46:29
    Story Summary: The second set is from a single hospital in northeast Thailand, and consists of 20 samples from patients who developed MRSA infection within 7 months of each other, all possibly linked by a chain of person-to-person transmissionWe wanted to test whether our method could successfully zoom in and out to allow us to [...] Related posts:MRSA bacteria mutates quickly as it spreads High-resolution gene technique zooms in on superbug Tracking a Superbug with Whole-Genome Sequencing

  • Hungry immune guardians are snappier

    Updated: 2010-01-24 11:15:27
    Story Summary: The majority of these microorganisms have been living with our bodys cells as good neighbours for millions of years. In this situation, even before the pathogenic germs invade our body, a mechanism is set in motion which acts completely independently of the classic immune defence systems. The biomedical researchers from the LIMES Institute [...] Related posts:Slimming gene discovered that regulates body fat Key feature of immune system survived in humans, other primates for 60 million years Promising Antimicrobial Attacks Virus, Stimulates Immune System

  • New gene discovered for recessive form of brittle bone disease

    Updated: 2010-01-24 10:02:27
    Story Summary: The finding was published online Jan. 20 in the New England Journal of Medicine. In addition, researchers at the University of Washington in Seattle and the NIHs National Institute of Human Genome Research also took part in the study. The NIHs National Institute of Arthritis and Musculoskeletal and Skin Diseases estimates that [...] Related posts:Tiny Rifts Create Fragility Of Brittle Bone Disease Tiny rifts create fragility of brittle bone disease Van Andel Institute researchers find gene that could lead to new therapies for bone marrow disease

  • Cholesterol-lowering drug shows promise against serious infections in sickle cell disease

    Updated: 2010-01-24 08:49:27
    Story Summary: The results provide the foundation for a possible future study to determine if statins, already widely used to lower cholesterol in adults, might protect children with sickle cell disease (SCD) from serious pneumococcal infection. In this study, scientists reported that statins prolonged the lives of mice with sickle cell disease following infection with [...] Related posts:New Approach To Sickle-Cell Disease Shows Promise In Mice Widely used cholesterol-lowering drug may prevent progression Breast cancer drug shows promise against serious infections

  • Potential new class of drugs to combat hepatitis C identified by Stanford scientists

    Updated: 2010-01-24 07:36:27
    Story Summary: There are many effective drugs for diseases caused by bacteria. Antibiotics, which fight bacterial infections, have revolutionized the treatment of contagious disease. Unlike bacteria, which multiply by dividing, a virus reproduces by breaking into cells and diverting their manufacturing machinery to produce copies of itself, which eventually depart the ravaged cell to find [...] Related posts:Identification Of Potential New Class Of Drugs To Combat Hepatitis C Eiger BioPharmaceuticals Announces Identification of a Novel Class of HCV Inhibitors Aileronas New Class of Drugs Shown to Get Inside Cells to Block Prime Cancer Target

  • VisEn Launches New Cat B 680 FAST(TM) Fluorescence Molecular Imaging Agent

    Updated: 2010-01-24 00:28:27
    Home About Archives Science Bookstore Terms of Service Privacy Policy Contact Us ADVERTISMENT ADVERTISMENT Tags choices imaging systems medicine quantification quantitative fluorescence VisEn Launches New Cat B 680 FAST(TM Fluorescence Molecular Imaging Agent Posted on 24 January 2010 12:28 by Alfie VN:F 1.8.1_1037 please wait . Rating : 0.0 5 0 votes cast Story : Summary The new Cat B 680 FAST(TM agent is designed to complement VisEns existing in vivo agent product lines , providing early imaging time points and an additional reporting wavelength for more multiplexing choices in cell-based and in vivo research study designs . VisEn agent brands include ProSense(r IntegriSense(TM AngioSense(TM OsteoSense(r MMPSense(TM Cat K FAST(TM Annexin-Vivo(TM and now OsteoSense(r 800, VivoTag(r 800 and Cat B 750 and 680 FAST(TM All VisEn agents and labels are designed for in vivo biomarker quantification using VisEns Fluorescence Molecular Tomography FMT(TM imaging systems , or for general use along with other non-quantitative fluorescence in vivo imaging systems . VisEn agents are also designed to enable complementary in vitro biomarker readouts in cells and tissues using standard

  • New Study Links Genetically Modified Crops to Organ Damage

    Updated: 2010-01-19 05:43:27
    (Beyond Pesticides, January 19, 2010) A study conducted by the Committee of Research and Information on Genetic Engineering (CRIIGEN) and the Universities of Caen and Rouen in France shows that three genetically modified (GM) crops have numerous adverse health effects on lab rats. The study analyzes raw data initially gathered by Monsanto to gain approval [...]

  • Study Finds Monsanto's GMO Corn Causes Organ Damage in Mammals.

    Updated: 2010-01-13 20:18:59
    A breakthrough report from the International Journal of Biological Sciences has found that three separate kinds of Monsanto's genetically modified corn causes organ damage in rats. Twilight Earth writes: "In what is being described as the first ever and most comprehensive study of the effects of genetically modified foods on mammalian health, researchers have linked organ damage with consumption of Monsanto's GM maize." All three of these kinds of corn have been approved by numerous food safety boards, and are widely available in the United States, Europe, and elsewhere. Links after the jump.

  • Greenpeace finds illegal GM maize in Rotterdam.

    Updated: 2010-01-13 20:18:00
    According to the environmental organisation Greenpeace (press release in German), GM maize that has not been approved in Europe has been imported to the EU. The maize, intended for animal feed, was found in a US shipment to Rotterdam in the Netherlands. Greenpeace analysed samples of conventional maize gluten from a ship unloading US maize. These samples contained 2.4 percent of the GM maize Herculex 59122. This maize is deregulated in the USA, but European approval is still pending and therefore imports of Herculex 59122 into the EU currently remain illegal. The European Commission has asked Dutch authorities to track down the maize shipment...

  • Aussie GM peas caused immune response in mice.

    Updated: 2010-01-13 20:15:05
    In late 2005, a private research institute in Australia, CSIRO Plant Industry, put a halt on the further development of a genetically modified pea cultivar responsible for causing an immune response in laboratory mice. Opposing sides of the public debate have taken these findings in conflicting directions. Some say the Australian findings confirm the effectiveness of screening processes, while for others, the results only prove that genetically modified plants are too unpredictable to reckon with.

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